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KMID : 0882420120830010132
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Korean Journal of Medicine
2012 Volume.83 No. 1 p.132 ~ p.135
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Renal Insufficiency Secondary to Leukemic Infiltration in Chronic Lymphocytic Leukemia: A Case Report
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Kim Jin-Suk
Kim Hyung-Yoon
Lee Han-Sang
Lee Hae-Ran
Kim Han-Seong
Park Ji-Yeon
Yi Seong-Yoon
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Abstract
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Renal infiltration is common in chronic lymphocytic leukemia (CLL), but renal impairment caused by leukemic infiltration is rare. This report describes the case of a 38-year-old man with CLL who required no medical treatment for 1 year and was admitted with nonoliguric renal insufficiency (proteinuria > 2,000 mg/day). A renal biopsy subsequently revealed leukemic infiltration by CLL. Treatment with fludarabine plus cyclophosphamide resulted in the improvement of renal function. Leukemic infiltration should be considered in the differential diagnosis of a patient with CLL and impaired renal function because renal impairment often responds well to chemotherapy.
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KEYWORD
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Chronic lymphocytic leukemia, Leukemic infiltration, Renal insufficiency, Proteinuria
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